4-(4-aminophenyl)butyric acid
4-(4-aminophenyl)butyric acid
CAS: 15118-60-2
Molecular Formula: C10H13NO2
4-(4-aminophenyl)butyric acid - Names and Identifiers
| Name | 4-(4-aminophenyl)butyric acid |
| Synonyms | AKOS BB-8810 4-Amino-benzenebutanoic p-Aminophenylbutyricacid p-Aminophenylbutyric acid 4-Aminophenylbutyric Acid 4-Aminobenzenebutanoic acid 4-(4-AMINOPHENYL)BUTYRIC ACID 4-(4-Aminophenyl)butanoicacid 4-(4-aminophenyl)butyric acid 4-(4-aminophenyl)butanoic acid |
| CAS | 15118-60-2 |
| EINECS | 628-142-4 |
| InChI | InChI=1/C10H13NO2/c11-9-6-4-8(5-7-9)2-1-3-10(12)13/h4-7H,1-3,11H2,(H,12,13) |
4-(4-aminophenyl)butyric acid - Physico-chemical Properties
| Molecular Formula | C10H13NO2 |
| Molar Mass | 179.22 |
| Density | 1.177±0.06 g/cm3(Predicted) |
| Melting Point | 121-124 °C (lit.)121-133 °C |
| Boling Point | 363.7±17.0 °C(Predicted) |
| Flash Point | 173.7°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 6.3E-06mmHg at 25°C |
| Appearance | Solid |
| Color | Light Beige to Light Brown |
| pKa | 4.70±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.583 |
| Physical and Chemical Properties | White crystals. Melting point 130-131 °c. Insoluble in cold water, soluble in ethanol and propanol, soluble in chloroform, insoluble in ether, benzene and petroleum ether. |
4-(4-aminophenyl)butyric acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
4-(4-aminophenyl)butyric acid - Reference Information
| Use | pharmaceutical intermediates for the synthesis of linokening. |
| production method | the condensation of succinic anhydride with acetanilide to produce β-p-acetamidobenzoyl propionic acid, it was obtained by reduction. Aluminum trichloride and carbon disulfide were added to the dry reaction pan, and stirred and cooled to 7-8 ° C., and a homogeneous mixture of acetanilide and succinic anhydride was quickly added. After vigorous reflux, the reaction was continued at 30-45 ° C. For 1 hour. Let stand for 2 days, put in crushed ice, stir and decompose, filter after 1H, wash the filter cake with 5% sodium bicarbonate solution, decolorize with activated carbon, filter, acidify the filtrate with 1.5N hydrochloric acid to pH = 1, A white solid was obtained, filtered, washed with water, dried, and refined with anhydrous ethanol to obtain β-p-acetylaminobenzoyl propionic acid, melting point 196-200 ℃, yield 35.4%. In the dry reaction pot, add β-acetamidobenzoyl propionic acid and hydrazine hydrate, heat to the external temperature of 140-160 ℃, keep the temperature for 20min and then cool to below 100 ℃. The reactant is a brown solid, potassium hydroxide was added slowly, and after being completely dissolved, it was reheated to an external temperature of 140 ° C. To start denitrification, and the temperature was further increased to 180 ° C., and the reactant was changed from thick to porous Yellow Pine solid. Nitrogen removal time is about 1H. After denitrification, cool, add water to dissolve, add activated carbon to decolorize and filter, neutralize the filtrate with 6N hydrochloric acid to pH 6, then adjust to pH5-6 with glacial acetic acid, precipitate milky white crystals, filter, wash with water, vacuum dry, 4-(p-aminobenzene) butyric acid. The yield was 85%. |
Last Update：2024-04-09 21:11:58
